程仲彬 博/硕士研究生导师 海南省D类高层次人才
邮箱:[email protected]/[email protected]
1.教育背景
2022.12-至今 色情网
副教授
2021.05-2022.11 河南大学色情网
副教授
2017.08-2021.04 河南大学色情网
讲师
2014.09-2017.06 北京大学色情网
生药学
2011.09-2014.06 中山大学色情网
生药学
2007.09-2011.06 中山大学色情网
药学
2.研究方向: 天然药物化学
微生物/药用植物代谢产物结构及功能研究（抗铁死亡/肿瘤/感染）
3.科研简介
在J. Nat. Prod.、Bioorg. Chem.、Mar. Drugs、Phytochemistry、Fitoterapia等领域内SCI期刊发表研究性论文40余篇，被引1000余次，H指数20。其中第一或通讯作者论文20余篇。Bioorg Chem、Fitoterapia、Nat Prod Res常邀审稿人。主持和参与多项国家级项目。曾获中国药学会优秀论文二等奖、河南省科技进步二等奖。中国菌物学会海洋与淡水菌物学专业委员会委员，Marine Drugs和MarineMedicine青年编委。
4.承担项目
1. 国家自然科学基金地区项目，82460683，在研，主持
2. 国家自然科学基金青年项目，81903536，结项，主持
3. 中国博士后科学基金第63批面上一等资助项目，2018M630815，结项，主持
4. 河南省青年托举工程项目，2020HYTP059，结项，主持
5. 河南省药品监督管理局-绿茶中药材标准，结项，主持
5.代表性成果
[1] Y. Zhang, H. Wang, J. Xiao, W. Xu, W. Liu, Z. Luo, P. Wu, X. Yang, Z. Zhang*, and Z. Cheng*. Agathic acid derivatives including a novel ferroptosis inhibitor from the fungus Penicillium thomii, Bioorg. Chem., 2025, 164, 108867.
[2] H. Wang, X. Ma, Y. Xi, Y. Li, S. Zhang, Y. Wang, C. Sai, Z. Cheng*, Z. Zhang*. Penichrysosterol, a novel dual inhibitor of ferroptosis and neuroinflammation from the deep-sea fungus Penicillium chrysogenum. Bioorg. Chem., 2025, 167, 108867.
[3] J. Ou, F. Zhong, P. Huang, Y. Zhang, …Z. Cheng*, H. Luo*. 2025. Hydroxychavicol derivatives from Piper betle Linn. as natural PDE4 inhibitors with anti-inflammatory effects. Bioorg. Chem. 2025, 157, 108294.
[4] J. Xiao, P. Wu, Y. Zhang, Q. Lv, Y. Chi, W. Xu, W. Lin*, Z. Cheng *. New polyketides and a ferroptosis inhibitor from the marine-derived fungus Diaporthe searlei CS-HF-1. Mar. Drugs 2025, 23, 402.
[5] S. Zhang, H. Wang, C. Sai, Y. Wang, Z. Cheng*, Z. Zhang*. The cytotoxic activity of secondary metabolites from marine-derived Penicillium spp.: A Review (2018–2024). Mar. Drugs 2025, 23, 197.
[6] Z. Zhang#, Y. Li#, H. Wang, W. Xu, C. Wang, H. Ma, …, Z. Cheng*. Ergone derivatives from the deep-sea-derived fungus Aspergillus terreus YPGA10 and 25,28-dihydroxyergone-induced apoptosis in human colon cancer SW620 Cells. J. Nat. Prod., 2024, 87:1563-1573.
[7] S. Han, H. Ma, Y. Wu, C. Wang, Y. Li, Q. Li, Z. Cheng*, Andrastin-type meroterpenoids, α-pyrone polyketides, and sesquicarane derivatives from Penicillium sp., a fungus isolated from Pinus koraiensis seed. Phytochemistry 2024, 225, 114202.
[8] H. Wang, L. Sun, X. Ma, S. Jin, Y. Xi, C. Sai, M. Yan, Z. Cheng*, Z. Zhang*, Polyketides and alkaloids from the fungus Aspergillus Fumigatus YB4-17 and ent-fumiquinazoline J induce apoptosis, paraptosis in human hepatoma HepG2 cells, Front. Pharmacol. 2024, 15, 1487977.
[9] Y. Lu, X. Zhao, M. Yuan, M. Zhao, K. Liu, M. Zhang, X. Qiu, X. Yu*, X. Liu*, D. Wei, J. Xie, Z. Cheng*, KYNU expression promotes cisplatin resistance in esophageal cancer, J. Cancer, 2024, 15, 2475-2485.
[10] Y. Li#, J. Shi#, R. Liu, Y. Liu, R. Liu, Z. Wu, W. Xu, H. Ma, H. Luo, Z. Cheng*. Structure revisions of phenolic bisabolane sesquiterpenes and a ferroptosis inhibitor from the marine-derived Fungus Aspergillus versicolor YPH93. J. Nat. Prod. 2023, 86, 830-841.
[11] Q. Li#, W. Xu#, R. Fan#, J. Zhang, Y. Li, X. Wang, S. Han, W. Liu, M. Pan, Z. Cheng*. Penithoketone and penithochromones A–L, polyketides from the deep-sea-derived fungus Penicillium thomii YPGA3, J. Nat. Prod. 2020, 83, 2679–2685.
[12] Z. Cheng*, W. Liu, R.Z. Fan, S.Y. Han, Y.L. Li, X.Y. Cui, J. Zhang, Y.N. Wu, X. Lv, Y. Zhang, Z. H. Luo, S.A. Alias, W. Xu*, Q. Li*, Terpenoids from the deep-sea-derived fungus Penicillium thomii YPGA3 and their bioactivities. Mar. Drugs, 2020, 18, 9.
[13] Y. Li, W. Liu, S. Han, J. Zhang, W. Xu, Q. Li and Z. Cheng*. Penitholabene, a rare 19-nor labdane-type diterpenoid from the deep-sea-derived fungus Penicillium thomii YPGA3, Fitoterapia, 2020, 146, 104691.
[14] Z. Cheng*, Y. Li, W. Xu, W. Liu, L. Liu, D. Zhu, Y. Kang, Z. Luo, Q. Li*. Three new cyclopiane-type diterpenes from a deep-sea derived Penicillium sp. YPGA11 fungus and their effects against human esophageal carcinoma cells. Bioorg. Chem. 2019, 91, 103129.
[15] Z. Cheng#, W. Xu#, Y. Wang, S. Bai, L. Liu, Z. Luo, W. Yuan*, Q. Li*. Two new meroterpenoids and two new monoterpenoids from the deep sea-derived fungus Penicillium sp. YPGA11. Fitoterapia, 2019, 133, 120-124.
[16] Z. Cheng#, Y. Li#, W. Liu, L. Liu, J. Liu, W. Yuan*, Z. Luo, W. Xu*, Q. Li*. Butenolide derivatives with α-glucosidase inhibitions from the deep-sea-derived fungus Aspergillus terreus YPGA10. Mar. Drugs, 2019, 17, 332.
[17] Z. Cheng#, W. Xu#, L. Liu, S. Li, W. Yuan, Z. Luo, J. Zhang, Y. Cheng, Q. Li*. Peniginsengins B–E, New farnesylcyclohexenones from the deep sea-derived fungus Penicillium sp. YPGA11. Mar. Drugs 2018, 16, 358.
[18] Z. Cheng#, D. Liu#, W. Cheng, P. Proksch, W. Lin*. Versiquinazolines L–Q, new polycyclic alkaloids from the marine-derived fungus Aspergillus versicolor. RSC Adv., 2018, 8, 31427-31439.
[19] Z. Cheng, L. Lou, D. Liu, X. Li, P. Proksch, S. Yin, W. Lin*. Versiquinazolines A-K, Fumiquinazoline-type alkaloids from the gorgonian-derived fungus Aspergillus versicolor LZD-14-1. J. Nat. Prod., 2016, 79, 2941-2952.
[20] Z. Cheng, J. Zhao, D. Liu, P. Proksch, Z. Zhao*, W. Lin*. Eremophilane-type sesquiterpenoids from an Acremonium sp. fungus isolated from deep-sea sediments. J. Nat. Prod., 2016, 79, 1035-1047.
[21] Z.-B. Cheng#, X. Lu#, J.-M. Bao, Q.-H. Han, Z. Dong, G.-H. Tang, L.-S. Gan*, H. Luo*, S. Yin*. (±)-Torreyunlignans A-D, rare 8-9¢ linked neolignan enantiomers as phosphodiesterase-9A inhibitors from Torreya yunnanensis. J. Nat. Prod., 2014, 77 (12), 2651-2657.
[22] Z.-B. Cheng#, Y.L. Deng#, C.Q. Fan, Q.H. Han, S.L. Lin, G.H. Tang, H. Luo*, S. Yin*. Prostaglandin derivatives: Nonaromatic phosphodiesterase-4 inhibitors from the soft coral Sarcophyton ehrenbergi. J. Nat. Prod. 2014, 77, 1928-1936.
[23] Z.B. Cheng#, W.W. Shao#, Y.N. Liu, Q. Liao, T.T. Lin, X.Y. Shen, S. Yin*. Extracellular signal-regulated kinases (ERK) inhibitors from Aristolochia yunnanensis. J. Nat. Prod., 2013, 76, 664-671.
